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Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive fibroinflammatory stromal reaction, which contributes to its hypovascular and hypoxic microenvironment. To assess the effects of hypoxia on fibroblast phenotype in an unbiased fashion, we performed RNA-sequencing profiling of mouse pancreatic stellate cells (PSCs) cocultured with mT3 PDAC cells exposed to normoxia (21% oxygen) or hypoxia (1% oxygen).

ORGANISM(S): Mus musculus

PROVIDER: GSE199012 | GEO | 2022/09/14

REPOSITORIES: GEO

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