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ScRNA-Seq analysis of Trim28-deleted NPp53 mouse prostate tissue

ABSTRACT: The Tripartite motif-containing 28 (TRIM28) transcription factor is upregulated in high-grade prostate cancers and was recently proposed as a therapeutic target for castration-resistant prostate cancers. To study the role of TRIM28 in prostate cancer progression in vivo, we used a genetically engineered mouse model, combining prostate-specific Trim28 inactivation with inactivation of Trp53 and Pten. We analyzed the prostates using single cell RNA-Seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE199015 | GEO | 2023/03/03

REPOSITORIES: GEO

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