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H3K9me3 Impedes Cell Fate Transition between 2C-Like and Pluripotent States [RNA-seq]

ABSTRACT: A small subgroup of embryonic stem cells (ESCs) exhibit molecular features similar to those of two-cell embryos (2C). Multiple chromatin modifiers associated with H3K9 trimethylation (H3K9me3) have been implicated in the mediation of the 2C-like transition. However, it remains elusive how H3K9me3 is remodeled and its association with totipotent cells. Here, we analyze the genome-wide change in H3K9me3 in 2C-like transitions. We revealed that a large fraction of trophoblast-stem-cell specific enhancers undergoes loss of H3K9me3 exclusively in MERVL+/Zscan4+ cells during 2C-like transitions.

ORGANISM(S): Mus musculus

PROVIDER: GSE199041 | GEO | 2022/12/01

REPOSITORIES: GEO

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