Transcriptomics

Dataset Information

0

Melanoma Differentiation Associated Gene-9/Syndecan Binding Protein (MDA-9/SDCBP) Promotes Hepatocellular Carcinoma (HCC)


ABSTRACT: The oncogene Melanoma differentiation associated gene-9/syndecan binding protein (MDA-9/SDCBP) promotes tumorigenesis and metastasis in many cancers. However, the role of MDA-9 in regulating HCC has not been well-studied. To unravel the function of MDA-9 in HCC we generated a transgenic mouse with hepatocyte-specific overexpression of MDA-9 (Alb/MDA-9). Alb/MDA-9 mice demonstrated significantly higher incidence of N-nitrosodiethylamine/phenobarbital-induced HCC compared to WT littermates. To check what genes are regulated by MDA-9 to promote HCC, RNA-seq was performed in naïve WT and Alb/MDA-9 hepatocytes.

ORGANISM(S): Mus musculus

PROVIDER: GSE199175 | GEO | 2023/12/27

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-06-14 | GSE206096 | GEO
| PRJNA818697 | ENA
2013-09-23 | E-GEOD-19913 | biostudies-arrayexpress
2013-09-23 | GSE19913 | GEO
2021-08-30 | GSE153223 | GEO
2021-07-07 | GSE169394 | GEO
2019-04-09 | PXD011249 | Pride
2023-01-06 | GSE203329 | GEO
2022-03-09 | GSE151733 | GEO
2017-10-30 | GSE106303 | GEO