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Identification of the transcriptional biomarkers set linked to pathological remodelling of the eye tissues in various HD mouse models.

ABSTRACT: Our study aims to identify transcriptional deregulation of the oculomotor transcriptome in various HD mouse models using an Affymetrix array analysis This study identified transciptome deregulation in the eye tissue of two HD mouse models, namely R6/1 and R6/2.

ORGANISM(S): Mus musculus

PROVIDER: GSE199335 | GEO | 2022/03/25

REPOSITORIES: GEO

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The CNS-Heart Axis is a Source of Cardiac Dysfunction in Mouse Models of Huntington’s Disease

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The CNS-Heart Axis is a Source of Cardiac Dysfunction in Mouse Models of Huntington's Disease

Project description:Purpose: Transcriptome profiling (RNA-seq) to microarray to evaluate transcriptional changes in the heart of HD mouse models Methods: Heart mRNA profiles of 4-weeks-old wild-type (WT) and R6/2 transgenic; 15-weeks-old WT and R6/2 transgenic mice; 8-month-old WT and HdhQ150 knock-in mice; 22-month-old WT and HdhQ150 knock-in mice were generated by deep sequencing, in triplicate, using Illumina Hi-seq 2000. Conclusions: Our study showed that there is no major transcriptional deregulation in the heart of mouse models of HD. Heart mRNA profiles of 4-weeks-old wild-type (WT) and R6/2 transgenic; 15-weeks-old WT and R6/2 transgenic mice; 8-month-old WT and HdhQ150 knock-in mice; 22-month-old WT and HdhQ150 knock-in mice were generated by deep sequencing, in triplicate, using Illumina Hi-seq 2000.

2014-07-15 | E-GEOD-58996 | biostudies-arrayexpress

Molecular correlation between mouse retina and striatum in HD

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Identification of the transcriptional biomarkers set linked to pathological remodelling of the eye tissues in various HD mouse models.

Project description:Identification of the transcriptional biomarkers set linked to pathological remodelling of the eye tissues in various HD mouse models.

| PRJNA819415 | ENA

Six-week-old R6/2 HD mouse striatum

2011-10-12 | E-GEOD-1980 | biostudies-arrayexpress

Identification of the Transcriptional Biomarkers Panel Linked to Pathological Remodelling of the Eye Tissues in Various HD Mouse Models.

Project description:Ocular abnormalities are becoming associated with a spectrum of pathological events in various neurodegenerative diseases. Huntington's disease (HD) is just such an example of a fatal neurological disorder, where mutated genes (CAG trinucleotide expansions in the Huntingtin gene) have widespread expression, leading to the production of mutant Huntingtin (mHTT) protein. It is well known that mutant HTT protein is prone to form toxic aggregates, which are a typical pathological feature, along with global transcriptome alterations. In this study, we employed well-established quantitative methods such as Affymetrix arrays and quantitative PCR (qPCR) to identify a set of transcriptional biomarkers that will track HD progression in three well-established mouse models: R6/2, R6/1, and HdhQ150. Our array analysis revealed significantly deregulated networks that are related to visual processes and muscle contractions. Furthermore, our targeted quantitative analysis identified a panel of biomarkers with some being dysregulated even at the presymptomatic stage of the disease, e.g., Opn1mw, Opn1sw, and Pfkfb2. Some of the deregulated genes identified in this study have been linked to other genetic ocular disorders such as: GNAT2, a source of achromatopsia, and REEP6, linked to Retinitis pigmentosa. It may thus be a useful platform for preclinical evaluations of therapeutic interventions.

| S-EPMC9139483 | biostudies-literature

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