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Adaptive and innate immune responses in MAC lung disease

ABSTRACT: Immunological mechanisms of susceptibility to NTM disease are poorly understood. We evaluated innate and antigen-specific adaptive immune responses to Mycobacterium avium complex in individuals with MAC lung disease. We investigated the gene expression changes induced in PBMCs by polyclonal stimulation (anti-CD3, anti-CD28), Mav and Mtb lysates and a peptide pool (MTB300) in individuals with MAC lung disease (MACDZ), and healthy controls (IGRA+ and IGRA-).

ORGANISM(S): Homo sapiens

PROVIDER: GSE199403 | GEO | 2022/09/23

REPOSITORIES: GEO

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