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Transcriptome analysis reveals the effect of LZ-8 on CD4+ T cells and CD8+ T cells [RNASeq3]

ABSTRACT: LZ-8 is a dimeric protein isolated from Ganoderma lucidum. It has immunomodulatory activity on T cells. In order to fully analyze the immunomodulatory effect of LZ-8 on CD4 + T cells and CD8 + T cells, we first sequenced the transcriptome of mouse T lymphocytes treated with LZ-8 for 15 hours, then compared the differential genes regulated by LZ-8 with those activated in CD4 + T cells and CD8 + T cells in GSE126116 data, and finally obtained the core biological process and signal pathway induced by LZ-8 to regulating the activation state of CD4 + T cells and CD8 + T cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE199521 | GEO | 2025/03/28

REPOSITORIES: GEO

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