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Transcriptome profile of ACE-expressing embryonic endothelial cells

ABSTRACT: During embryonic development, blood cells emerge from a subset of specialized endothelial cells, named hemogenic endothelial cells (HECs) via a process known as endothelial-to-hematopoietic transition (EHT). A more thorough characterization of HECs is essential to guide the efforts to derive this population from human pluripotent stem cells (hPSCs), a critical step to generate therapeutic blood products in vitro. To identify specific human HEC markers, we performed transcriptomic analysis of 28-32-day human embryos, a developmental stage characterized by active EHT.

ORGANISM(S): Homo sapiens

PROVIDER: GSE199578 | GEO | 2024/02/09

REPOSITORIES: GEO

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