Transcriptomics

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Transcriptome comparsion of WT and CD300ld KO PMN-MDSC


ABSTRACT: Polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC), also named pathologically activated neutrophil, is a critical component of tumor microenvironment (TME), playing crucial roles in tumor progression and therapy resistance. CD300ld is specifically expressed in normal neutrophils and is upregulated in PMN-MDSCs upon tumor bearing. CD300ld knockout (KO) inhibits the development of multiple tumor types in a PMN-MDSC-dependent manner. Here, we compared the transcriptome of PMN-MDSCs from WT mice and CD300ld KO mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE199602 | GEO | 2023/06/26

REPOSITORIES: GEO

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