Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of Setx KI and WT Spinal Cord

ABSTRACT: The goal of this study is to compare differences in splicing between bulk spinal cord samples isolated from Setx KI and WT mice

ORGANISM(S): Mus musculus

PROVIDER: GSE199664 | GEO | 2022/04/22

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA-seq of Setx KI and WT Spinal Cord

Project description:RNA-seq of Setx KI and WT Spinal Cord

| PRJNA821102 | ENA

SMART-seq of PD1+ and PD1- CD8 T cells derived from Setx L389S (Setx KI) mice

Project description:The goal is to understand the nature of PD-1+ CD8 T cells that are detected in the peripheral blood of ALS4 mice (expressing the mutation SetxL389S, also called Setx KI mice). We performed a SMART (Switching Mechanism At the end of the 5’-end of the RNA Transcript)-sequencing analysis of the transcriptome of effector memory CD8 T cells expressing or not PD-1 from the blood of symptomatic KI animals. Amongst the transcripts differentially expressed between these two populations, we detected upregulation of Tox (Thymocyte Selection Associated High Mobility Group Box) in PD-1+ as compared to PD-1- CD8 T cells.

2022-04-22 | GSE199663 | GEO

Protein profile of spinal cord lysates from EV71 infected WT and TLR7KO mice

Project description:Analysis of protein profile of spinal cord lysates from EV71-infected WT and TLR7KO mice at the recovery phase

2020-10-06 | MSV000086240 | MassIVE

Spinal cord injury

Project description:Spinal cord injury

| PRJNA532533 | ENA

SMART-seq of PD1+ and PD1- CD8 T cells derived from Setx L389S (Setx KI) mice

Project description:SMART-seq of PD1+ and PD1- CD8 T cells derived from Setx L389S (Setx KI) mice

| PRJNA821103 | ENA

Danio spinal cord injury

Project description:Adult zebrafish have the ability to recover from spinal cord injury and exhibit re-growth of descending axons from the brainstem to the spinal cord. We performed gene expression analysis using microarray to find damage-induced genes after spinal cord injury, which shows that Sox11b mRNA is up-regulated at 11 days after injury. However, the functional relevance of Sox11b for regeneration is not known. Here, we report that the up-regulation of Sox11b mRNA after spinal cord injury is mainly localized in ependymal cells lining the central canal and in newly differentiating neuronal precursors or immature neurons. Using an in vivo morpholino-based gene knockout approach, we demonstrate that Sox11b is essential for locomotor recovery after spinal cord injury. In the injured spinal cord, expression of the neural stem cell associated gene, Nestin, and the proneural gene Ascl1a (Mash1a), which are involved in the self-renewal and cell fate specification of endogenous neural stem cells, respectively, is regulated by Sox11b. Our data indicate that Sox11b promotes neuronal determination of endogenous stem cells and regenerative neurogenesis after spinal cord injury in the adult zebrafish. Enhancing Sox11b expression to promote proliferation and neurogenic determination of endogenous neural stem cells after injury may be a promising strategy in restorative therapy after spinal cord injury in mammals. Spinal cord injury or control sham injury was performed on adult zebrafish. After 4, 12, or 264 hrs, a 5 mm segment of spinal cord was dissected and processed (as a pool from 5 animals) in three replicate groups for each time point and treatment.

2010-10-19 | E-GEOD-20460 | biostudies-arrayexpress

Transcriptome analysis of spinal cord microglia and total spinal cord

Project description:Transcriptome analysis of spinal cord microglia and total spinal cord from Lewis rats intratracheally treated with PBS, neomycin or vancomycin.

2021-12-21 | GSE192411 | GEO

Transcriptome analysis of spinal cord microglia and total spinal cord

Project description:Transcriptome analysis of spinal cord microglia and total spinal cord

| PRJNA791374 | ENA

Proteomics analysis of zebrafish spinal cord regeneration

Project description:Label-free mass spectrometry-based quantitative proteomics was applied to a larval zebrafish spinal cord injury model, which allows axon regeneration and functional recovery within two days (days post lesion; dpl) after a spinal cord transection in 3 day-old larvae (dpf). Proteomic profiling of the lesion site was performed at 1 dpl and 2 dpl as well as corresponding age-matched unlesioned control tissue (4 dpf as control for 1 dpl; 5 dpf as control for 2 dpl).

2023-09-06 | PXD037590 | Pride

Danio spinal cord injury

2010-10-19 | GSE20460 | GEO