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Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevity

ABSTRACT: Treating Saccharomyces cerevisiae cells with myriocin reduces the intracellular free pool of most amino acids. We find that transcriptional changes within the first 6 hours of drug treatment seem to have little impact on free pool changes. Rather the changes are driven early by post-translational events including impaired amino acid transporter activity, due to a reduced rate of sphingolipid biosynthesis, and an increased rate of endocytosis of at least some amino acid transporters, particularly the major methionine transporter Mup1.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE199904 | GEO | 2023/01/01

REPOSITORIES: GEO

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