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Investigation of bone marrow microenvironment-induced drug resistance in acute lymphoblastic leukemia (ALL)

ABSTRACT: Bulk RNA-seq of B-ALL cells cocultured with bone marrow-mesenchymal stem cells (BM-MSC) identified that B-ALL acquire epithelial-mesenchymal transition (EMT) properties by interacting with primary bone marrow-mesenchymal stem cells (BM-MSC) and scRNA-seq dissected the hybrid cluster of adherent B-ALL (Adh B-ALL) harboring B-ALL and BM-MSC features induced by EMT program

ORGANISM(S): Homo sapiens

PROVIDER: GSE200039 | GEO | 2022/05/31

REPOSITORIES: GEO

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