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Investigating the effects of different HMGB1 redox isoforms on macrophage polarization

ABSTRACT: Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. In different conditions, macrophage polarization can be induced by high-mobility group box 1 (HMGB1), a nuclear DNA-binding protein that activates innate immunity. This study investigated the phenotypes of murine bone-marrow-derived macrophages (BMDMs) induced by different HMGB1 redox isoforms via bulk RNA sequencing (RNAseq).

ORGANISM(S): Mus musculus

PROVIDER: GSE200210 | GEO | 2022/06/02

REPOSITORIES: GEO

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Investigating the effects of different HMGB1 redox isoforms on macrophage polarization

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