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Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE200402 | GEO | 2022/07/12

REPOSITORIES: GEO

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Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells [RNA-seq]

Project description:We have shown that the expression of the endoplasmic reticulum stress sensor Creb3l1 increases in magnocellular neurones (MCNs) in the rat hypothalamus in response to increased physiological demands for protein synthesis. Here we adopted a multiomic strategy to investigate specific roles of Creb3l1 in MCN homeostasis. We first performed chromatin immunoprecipitation followed by genome sequencing (ChIP-seq) to identify Creb3l1 genomic targets in the water deprived MCN enriched hypothalamic preparation. We then compared ChIP-seq gene targets with water deprived and Creb3l1 knockdown supraoptic nucleus RNA sequencing transcriptome datasets. This has provided an integrated signalling-gene regulation network for this transcription factor illuminating changes to cell pathways and function, an approach that has led us to understand the physiological changes that occur in MCNs to cope with excessive protein demands.

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Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells [ChiP-seq]

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Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells

Project description:Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells

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Project description:Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells [ChiP-seq]

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