RT-qPCR analysis of apoptosis related genes in patient-derived xenografts of small intestine neuroendocrine tumors in Balb/c NM after administration of Lu-177-octreotate, Lu-177-octreotate + A1M and A1M

ABSTRACT: This work aimed to examine the regulation of apoptosis-related genes in GOT1 tumors one and seven days after administration of 177Lu-octreotate with and without A1M and of A1M alone. At study start, 22 adult female Balb/c GOT1 tumor-bearing mice were divided into four groups of six animals that received 30 MBq 177Lu-octreotate or 5 mg/kg A1M, or co-treatment with both 177Lu-octreotate and A1M by i.v. injection. Also, a control group was sham-treated with saline. Half of the animals in each treatment and control group were terminated by cardiac puncture one-day post-injection (1 dpi), and the remaining animals were terminated at 7dpi. Tumor tissues were dissected at the time of termination, snap-frozen in liquid nitrogen and stored at -80°C.

ORGANISM(S): Homo sapiens

PROVIDER: GSE200449 | GEO | 2023/04/25

REPOSITORIES: GEO