Transcriptomics

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Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes


ABSTRACT: We found piRNAs with different lengths represented the predominant small RNA species in oocytes from the 12 explored species, except mouse. We found endo-siRNAs resulted from the truncated Dicer isoform were mouse-specific, and os-piRNAs associating with PIWIL3 in human oocytes are widespread in mammals and are typically with low levels of the 2’-3’-O-methylation. The sequences of many highly expressed piRNA clusters are fast-evolving compared with their syntenic genomic locations, and the TE families distributing in the conserved piRNA clusters are various between species.

ORGANISM(S): Mesocricetus auratus Mus musculus Danio rerio Rattus norvegicus Sus scrofa domesticus Canis lupus familiaris Cavia porcellus Macaca fascicularis Homo sapiens Oryctolagus cuniculus Cricetulus griseus Capra hircus

PROVIDER: GSE200470 | GEO | 2024/03/06

REPOSITORIES: GEO

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