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Analysis of Age-Dependent Transcriptomic Changes in Response to Intracerebral Hemorrhage in Mice

ABSTRACT: To investigate age-dependent transcriptomic changes between young or aged intracerebral hemorrhage mice, we established collagenase IV-induced intracerebral hemorrhage mice models. Intracerebral hemorrhage was induced by infusion of sterile collagenase IV in ipsilateral caudate putamen of brain. We then performed gene expression profiling analysis using data obtained from RNA-seq of brain perihematomal tissues from young or aged ICH mice 24 hours after intracerebral hemorrhage.

ORGANISM(S): Mus musculus

PROVIDER: GSE200575 | GEO | 2022/04/29

REPOSITORIES: GEO

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Project description:Tandem mass tag (TMT)-based proteomics was utilized to examine the protein expression profiles of perihematomal tissue from young and aged mouse models 24 hours after collagenase IV-induced ICH.

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