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Effect of cardiac specific depletion of Mrps5 on gene expression in heart at 12 weeks after gene knockout

ABSTRACT: To understand the molecular mechanism underlying Mrps5 function in the heart, we performed RNA sequencing of Mrps5cKO and Mrps5fl/fl hearts 12 weeks after tamoxifen induction. We chose this stage because the mutant hearts have just started to exhibit detectable defects and the changes in the transcriptome state would more accurately correlate with the onset of the phenotype.

ORGANISM(S): Mus musculus

PROVIDER: GSE200940 | GEO | 2023/02/14

REPOSITORIES: GEO

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