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Fluorescent tracking identifies tumor migratory dendritic cells as critical for cross-presentation in the lymph node following radiation therapy induced maturation

ABSTRACT: To understand the early effect of radiation therapy on tumor-infiltrating immune cells in two different tumor types, we established MC38 or Panc02-SIY tumors in C57BL/6 mice. scRNASeq was performed on CD45+ cells sorted by flow cytometry from single cell suspensions of tumors 1 day following 12Gy radiation therapy (RT), or control untreated (NT) tumors.

ORGANISM(S): Mus musculus

PROVIDER: GSE201026 | GEO | 2022/04/24

REPOSITORIES: GEO

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p53 suppresses MHC class II antigen presentation by the intestinal epithelium to protect intestinal stem cells upon radiation

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Gene regulation in macrophages from irradiated tumors

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Fluorescent tracking identifies tumor migratory dendritic cells as critical for cross-presentation in the lymph node following radiation therapy induced maturation

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| PRJNA828105 | ENA

Gene regulation in macrophages from irradiated tumors

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Single-cell RNAseq of CD45 positive cells in MC38 tumors - Primary irradiated tumors and secondary non-irradiated tumors - Concurrent treatment with anti-PD-L1

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Non-homogenous intratumor ionizing radiation doses synergize with PD1 and CXCR2 blockade

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Profiling the inflammatory signatures of bulk MC38, Pan02 and KPC tumors from wild-type mice and Sirpα-KO mice before and after radiation therapy

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