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Adeno-associated virus (AAV) 9-mediated gene delivery of Nurr1 and Foxa2 cures symptoms and pathologies of Alzheimer disease model mice by suppressing neuro-inflammation and glial pathology.

ABSTRACT: In this study, AAV9-Nurr1 and AAV9-Foxa2 (or AAV9-Control as sham-operated control) were injected to hippocampus of 15-18 months old 3xTg Alzheimer's disease mice. And mouse hippocampal glia were primarily cultured at postnatal day 1 and forced expression of Nurr1 and Foxa2 with lentivirus (or lenti-Control).

ORGANISM(S): Mus musculus

PROVIDER: GSE201106 | GEO | 2022/04/23

REPOSITORIES: GEO

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Microarray analysis of Nurr1 and Foxa2 synergisitic effect for DA neuron induction

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