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PGE2-EP3 axis controls brown adipose tissue development through stabilization of WTAP protein

ABSTRACT: By conducting CUT&TAG, we reported that brown adipogenesis induction markedly increased ZFP410 occupancy on chromatin. GO analysis revealed that genes containing the ZFP410-bound peaks were enriched in fat cell differentiation. Consistently, binding signals of ZFP410 on the promoter regions of CHD4 as well as brown genes such as Pgc-1a, Prdm16 and Cyto C were markedly increased in differentiated pre-adipocytes compared to those in control cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE201304 | GEO | 2022/04/25

REPOSITORIES: GEO

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PGE2-EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase

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