Transcriptomics

Dataset Information

0

Construction of the axolotl cell landscape using combinatorial hybridization sequencing at single cell resolution [scRNA-seq]


ABSTRACT: Here, we developed a single-cell sequencing method based on combinatorial hybridization to generate a tissue-based transcriptomic landscape of the neotenic and metamorphosed axolotl. We performed gene expression profiling of over 1 million single cells across 19 tissues to construct the first adult axolotl cell landscape. Comparison of single-cell transcriptomes between the tissues of neotenic and metamorphosed axolotls revealed the heterogeneity of non-immune parenchymal cells in different tissues and established their regulatory network. Furthermore, we described dynamic gene expression patterns during limb development in neotenic axolotls. This system-level single-cell analysis of molecular characteristics in neotenic and metamorphosed axolotls, serves as a resource to explore the molecular identity of the axolotl and facilitates better understanding of metamorphosis.

ORGANISM(S): Mus musculus Homo sapiens Ambystoma mexicanum

PROVIDER: GSE201446 | GEO | 2022/06/17

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-06-17 | GSE182746 | GEO
2023-09-20 | GSE243225 | GEO
2018-07-29 | E-MTAB-6092 | biostudies-arrayexpress
2012-01-31 | E-GEOD-35255 | biostudies-arrayexpress
2016-07-05 | E-GEOD-71934 | biostudies-arrayexpress
2017-03-07 | GSE79299 | GEO
2018-12-01 | GSE95355 | GEO
| PRJNA831808 | ENA
| PRJNA757699 | ENA
2024-08-29 | GSE271056 | GEO