Transcriptomics

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Construction of the axolotl cell landscape using combinatorial hybridization sequencing at single cell resolution [scRNA-seq]


ABSTRACT: Here, we developed a single-cell sequencing method based on combinatorial hybridization to generate a tissue-based transcriptomic landscape of the neotenic and metamorphosed axolotl. We performed gene expression profiling of over 1 million single cells across 19 tissues to construct the first adult axolotl cell landscape. Comparison of single-cell transcriptomes between the tissues of neotenic and metamorphosed axolotls revealed the heterogeneity of non-immune parenchymal cells in different tissues and established their regulatory network. Furthermore, we described dynamic gene expression patterns during limb development in neotenic axolotls. This system-level single-cell analysis of molecular characteristics in neotenic and metamorphosed axolotls, serves as a resource to explore the molecular identity of the axolotl and facilitates better understanding of metamorphosis.

ORGANISM(S): Mus musculus Homo sapiens Ambystoma mexicanum

PROVIDER: GSE201446 | GEO | 2022/06/17

REPOSITORIES: GEO

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