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Transcriptional analysis of primary astrocytes from human fœtal brain inflamed or not with IL-1 beta and subsequently exposed to IL-27

ABSTRACT: To examine the broad impact of IL-27 on human astrocytes, we performed a microarray analysis assessing >20,000 well annotated genes on primary astrocytes culture from four fetal brain donors. Astrocytes were inflamed or not using human recombinant IL-1 beta (20 ng/mL) befor being exposed or not to human recombinant IL-27 (100 ng/mL). Our goal was to investigate the impact of interleukin-27 on the gene expression profil of human astrocytes

ORGANISM(S): Homo sapiens

PROVIDER: GSE201555 | GEO | 2022/09/15

REPOSITORIES: GEO

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