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Dissecting genetic components associated with eye disease using integrative genomic analysis [Capture HiC]


ABSTRACT: GWAS studies have revealed thousands of variants strongly associated with AMD, yet connecting these variants to their cognate genes has not been explored. In this study we fine-mapped AMD risk loci and examined long-range cis chromatin interactions at essential genes of RPE function and disease-associated variants in iPSC-induced retinal pigmented epithelium (RPE) and primary RPE.

ORGANISM(S): Homo sapiens

PROVIDER: GSE201678 | GEO | 2022/04/30

REPOSITORIES: GEO

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