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The histone modification change between PRC2-wt and PRC2-loss in human MPNST cancer cells

ABSTRACT: PRC2-isogenic human malignant peripheral nerve sheath tumor (MPNST) M3 cells were generated through CRISPR/Cas9-mediated knockout of the PRC2 core component, SUZ12. PRC2 loss leads to global loss of H3K27me3, which causes H3K27ac redistribution and also affect other histone modification, e.g., H3K36me2/3.

ORGANISM(S): Homo sapiens

PROVIDER: GSE202555 | GEO | 2022/08/17

REPOSITORIES: GEO

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