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BHLHE40 is key hypoxia-induced transcriptional repressor in beta cells

ABSTRACT: To assess the impact of hypoxia on global gene expression of beta cells, we performed bulk RNA-seq on mouse islets, human islets and MIN6 cells. Bhlhe40 was transcriptional repressor which was highly induced by hypoxia in beta cells. Thus, we established Bhlhe40 overexpressing MIN6 cells and performed RNA-seq to identify the targets of Bhlhe40.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE202603 | GEO | 2023/05/01

REPOSITORIES: GEO

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BHLHE40 is key hypoxia-induced transcriptional repressor in beta cells

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