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Single-cell RNA sequencing shows the heterogeneity of cancer-associated fibroblast in HBV-related hepatocellular carcinoma

ABSTRACT: We identified 5 distinct fibroblast subsets by sequencing 74957 single cells derived from 7 HBV-related HCC tissues, of which the CD36+ CAFs were highlighted, with enriched lipid metabolism and secreting high levels of macrophage migration inhibitory factor (MIF). CD36+ CAFs had tight interactions with CD33+ MDSCs through MIF/CD74 axis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE202642 | GEO | 2023/03/13

REPOSITORIES: GEO

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