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Synergistic function screening of multiple checkpoint perturbation in TIL


ABSTRACT: A synergistic function screening system was established, in which a multiplexed CRIPSR knockout library targeting different checkpoint combinations was constructed and transduced into CD8+T cells to block multiple checkpoints in single cell. Based on this system, we performed a in vivo synergistic function screening of several checkpoints in tumor infiltrating CD8+T cells and find the best combined checkpoint blockade strategy to boost the CD8+T cell-mediated tumor elimination in vivo.

ORGANISM(S): Mus musculus

PROVIDER: GSE202653 | GEO | 2022/06/15

REPOSITORIES: GEO

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