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Flattened circadian glucocorticoid oscillations cause obesity due to increased lipid turnover and lipid uptake

ABSTRACT: Chronic stressors flatten circadian glucocorticoid (GC) oscillations, which has been correlated with negative health outcomes including obesity. How such flattened circadian GC oscillations affect metabolism and fat storage remains unknown. Here we investigated the consequences in mice and found that flattening of GC oscillations results not only in body weight gain, mainly due to increases in white fat depot mass, but also leads to hyperinsulinemia and fat accumulation in brown adipose tissue. Global analysis of the transcriptome of WAT and BAT revealed alterations in gene expression dependent on flattened GC oscillations and point to increased lipid turnover and lipid uptake in both fat depots.

ORGANISM(S): Mus musculus

PROVIDER: GSE202800 | GEO | 2022/05/13

REPOSITORIES: GEO

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Flattened circadian glucocorticoid oscillations cause obesity due to increased lipid turnover and lipid uptake

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