Transcriptomics

Dataset Information

0

Genome-wide transcriptomic profiling of human iPS-derived cardiomyocytes in response to ectopic expression of SARS-CoV-2 proteins


ABSTRACT: In this study, we investigated the effects of SARS-CoV-2 subunits on cardiomyocytes derived from human stem cells. The human induced pluripotent stem cells (hiPSCs) was differentiated into cardiomyocytes, and then were transfected with plasmids carrying different SARS-CoV-2 subunits. The cardiac functions, such as contractility and metabolic profiles, were investigated. We found the subunits 9B and S proteins has significantly adversed effects on the cardiac functions, compared to other groups. Thus, changes in transcriptome of cardiomyocytes (day30) after over expression of 9B, S for two days (on day 32) and two weeks (on day 45) were investigated by RNA-seq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE202869 | GEO | 2023/02/02

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-09-21 | GSE156754 | GEO
2022-04-09 | GSE185602 | GEO
2010-12-01 | E-GEOD-22581 | biostudies-arrayexpress
2020-06-19 | GSE150392 | GEO
2013-05-28 | E-GEOD-11704 | biostudies-arrayexpress
2023-12-31 | GSE239372 | GEO
2022-09-26 | PXD033492 | Pride
2022-02-23 | GSE171370 | GEO
2023-05-04 | GSE230227 | GEO
2014-10-31 | E-GEOD-52920 | biostudies-arrayexpress