Transcriptomics

Dataset Information

0

Accumulation of auranofin in white adipose tissues lowers leptin levels and exerts anti-diabetic effects


ABSTRACT: Low-grade, sustained inflammation in white adipose tissue (WAT) characterizes obesity and frequently coincides with insulin resistance and type 2 diabetes (T2D). However, pharmacological targeting of WAT inflammation lacks durable therapeutic effects. Through a computational screen, we identified the FDA-approved rheumatoid arthritis drug auranofin is a putative small molecule for obesity treatment. We discovered that allometrically scaled safe auranofin doses homed to WAT and improved insulin sensitivity in obese wild-type mice. To assess the transcriptional changes underlying the beneficial effects of auranofin, we performed RNA-seq analysis on adipose and liver tissue after 4 weeks of treatment with vehicle or auranofin.

ORGANISM(S): Mus musculus

PROVIDER: GSE202935 | GEO | 2022/10/06

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-06-30 | GSE236110 | GEO
2021-07-01 | GSE159397 | GEO
2019-04-03 | GSE126135 | GEO
2024-08-28 | GSE255950 | GEO
2011-04-30 | E-GEOD-23736 | biostudies-arrayexpress
2020-09-01 | GSE151092 | GEO
2024-05-24 | PXD038334 | Pride
2019-02-25 | GSE117353 | GEO
2018-12-23 | GSE66131 | GEO
2018-12-23 | GSE66130 | GEO