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Evidence for a unique RNA motif in orchestrating Orthomyxoviridae splicing

ABSTRACT: Our laboratory has generated evidence that Archaean L7Ae serves as a unique inhibitor of orthomyxovirus splicing, and as such, can inhibit replication of this class of viruses. Here, we utilize RNA-sequencing to analyze how Archaean L7Ae impacts the transcriptome of a human cell line. Results showed that L7Ae had minimal impact on host transcriptonal response despite retaining its properties to inhibit orthomyxovirus replication.

ORGANISM(S): Homo sapiens

PROVIDER: GSE202990 | GEO | 2023/03/11

REPOSITORIES: GEO

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Evidence for a unique RNA motif in orchestrating 2 Orthomyxoviridae splicing

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