Transcriptomics

Dataset Information

0

β2-microglobulin maintains glioblastoma stem cells and induces M2-like polarization of tumor-associated macrophages


ABSTRACT: Glioblastoma (GBM) is a complex ecosystem that includes a heterogeneous tumor population and the tumor immune microenvironment (TIME), prominently containing tumor- associated macrophages (TAM) and microglia. Here, we dem- onstrated that β2-microglobulin (B2M), a subunit of the class I major histocompatibility complex (MHC-I), promotes the maintenance of stem-like neoplastic populations and repro- grams the TIME to an anti-inflammatory, tumor-promoting state. B2M activated PI3K/AKT/mTOR signaling by interacting with PIP5K1A in GBM stem cells (GSC) and promoting MYC- induced secretion of transforming growth factor-β1 (TGFβ1). Inhibition of B2M attenuated GSC survival, self-renewal, and tumor growth. B2M-induced TGFβ1 secretion activated para- crine SMAD and PI3K/AKT signaling in TAMs and promoted an M2-like macrophage phenotype. These findings reveal tumor-promoting functions of B2M and suggest that targeting B2M or its downstream axis may provide an effective approach for treating GBM.

ORGANISM(S): Homo sapiens

PROVIDER: GSE203074 | GEO | 2022/06/30

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-09-11 | GSE157779 | GEO
2024-08-01 | GSE273250 | GEO
2024-08-01 | GSE273252 | GEO
2014-09-11 | GSE61335 | GEO
2019-10-02 | GSE138236 | GEO
2024-09-04 | GSE264212 | GEO
2022-08-02 | PXD029393 | Pride
2023-03-11 | PXD027069 | Pride
2021-12-01 | GSE179667 | GEO
2023-03-10 | PXD033913 | Pride