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Accessible chromatin differences in FCRL5 positive and negative influenza-specific memory B cells

ABSTRACT: We examined the accessible chromatin differences between circulating B cell subsets post-vaccination. Using FCRL5 as a marker of Tbet expressing B cells, we sorted FCRL5+ (Tbet+) and FCRL5- (Tbet-) memory B cells, and antibody secreting plasmablasts at day 7 and day 14 post-vaccination. Additionally, we used H1 B cell tetramers to track cells responding to the influenza vaccine in a subset of samples. These data provide insights into the accessible chromatin landscape of distinct B cell subsets that respond to influenza vaccination.

ORGANISM(S): Homo sapiens

PROVIDER: GSE203112 | GEO | 2023/03/01

REPOSITORIES: GEO

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