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The role of GCN2 kinase in amino acid dependent longevity and feeding behaviour in Drosophila

ABSTRACT: Dietary amino acids restriction extends lifespan in diverse species ranging from flies to mammals. The evolutionarily conserved serine/threonine kinase General Control Nonderepressible 2 (GCN2) is a key sensor of amino acid deficiency and has been implicated in lifespan regulation upon dietary restriction. However, the role of individual essential amino acids (EAA) in modulating organismal lifespan and the underlying molecular mechanisms through which EAA mediate these effects are only partially understood. We generated a novel Drosophila GCN2 null mutant and systematically analyzed its response to individual amino acid deficiency.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE203210 | GEO | 2022/06/03

REPOSITORIES: GEO

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