Thy1 Marks a Distinct Population of Slow-Cycling Stem Cells in the Mouse Epidermis

ABSTRACT: Here, we report a discrete population of keratinocytes, marked by Thy1, in the basal layer of the IFE. We find that basal keratinocytes expressing differential levels of Thy1 display distinct transcriptional signatures. Thy1+ keratinocytes do not express T cell markers, express a unique transcriptional profile, cycle significantly slower than epidermal progenitors and display significant expansion potential in vitro. Collectively, these results reveal a distinct stem cell population that plays a critical role in epidermal homeostasis and repair.

ORGANISM(S): Mus musculus

PROVIDER: GSE203405 | GEO | 2022/05/24

REPOSITORIES: GEO