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Follicular lymphoma microenvironment characteristics associated with tumor cell mutations and MHC class II expression

ABSTRACT: Follicular lymphoma (FL) is a B-cell lymphoma with a complex tumor microenvironment that is rich in non-malignant immune cells. We applied single-cell RNA-sequencing to characterize the immune microenvironment of FL. This provides a classification framework of the FL microenvironment, their association with FL genotypes and antigen presentation, and informs different potential immunotherapeutic strategies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE203610 | GEO | 2022/05/28

REPOSITORIES: GEO

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Microenvironment subtypes and association with tumor cell mutations and antigen expression in follicular lymphoma

Project description:Follicular lymphoma (FL) is a B-cell lymphoma with a complex tumor microenvironment that is rich in non-malignant immune cells. We applied single-cell RNA-sequencing to characterize the immune microenvironment of FL. This provides a classification framework of the FL microenvironment, their association with FL genotypes and antigen presentation, and informs different potential immunotherapeutic strategies.

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Abberant Cathepsin S Activity Modulates the Immune Microenvironment in Follicular Lymphoma

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Follicular lymphoma microenvironment characteristics associated with tumor cell mutations and MHC class II expression

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Follicular Lymphoma Microenvironment Characteristics Associated with Tumor Cell Mutations and MHC Class II Expression.

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