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Comparison of CD133 high and CD133 negative cell populations isolated from colorectal carcinoma and liver metastases

ABSTRACT: Microarray-based gene expression analysis identified genes differentially expressed between CD133 high and CD133 negative cell populations isolated from colorectal carcinoma and liver metastases

ORGANISM(S): Homo sapiens

PROVIDER: GSE20459 | GEO | 2011/02/17

SECONDARY ACCESSION(S): PRJNA125119

REPOSITORIES: GEO

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Comparison of CD133 high and CD133 negative cell populations isolated from colorectal carcinoma and liver metastases

Project description:Microarray-based gene expression analysis identified genes differentially expressed between CD133 high and CD133 negative cell populations isolated from colorectal carcinoma and liver metastases In this study, a set of 5 colorectal cancers was used to acquire expression profiles, leading to the identification of differentially expressed genes between CD133 high and CD133 negative cell populations by Significance Analysis of Microarray dada.

2011-02-17 | E-GEOD-20459 | biostudies-arrayexpress

Lgr5-negative cancer cells seed metastases in colorectal cancer

Project description:Cancer stem cells (CSCs) are a minority population of cancer cells that display stem cell-like multipotent and self-renewal properties. They give rise to the bulk of cancer cells with limited replicative potential. In colorectal cancer (CRC), CSCs are marked by expression of the leucine-rich repeat-containing G-protein receptor 5 (Lgr5). Since CSCs display multipotent and self-renewal properties, this population is thought to seed metastases. Here, we used a mouse model and human xenografts to investigate the cell-of-origin of metastases. Surprisingly, we found that most CRC cells that disseminated and entered the blood circulation were Lgr5-. Lgr5- cancer cells arriving at the metastatic site formed lesions in which Lgr5+ CSCs appeared. This plasticity could occur independently of stemness-inducing factors, and was an indispensable event for the outgrowth of metastases, since neutralization of this plasticity prevented metastatic outgrowth. Combined, our study shows that most metastases are seeded by Lgr5- cancer cells, and that these cells have a niche-independent and intrinsic capacity to become CSCs and restore epithelial hierarchy.

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Project description:Comparison of expression profiles of primary colorectal cancers with liver metastases of the same patient. Additionally, expression data of normal colon and liver tissue. Abstract of publication will be included upon publication Keywords: expression profiling, colorectal cancer, colon cancer, liver metastasis, normal colonic tissue, normal liver tissue RNA of 18 primary colorectal cancers, 18 matched liver metastases, 7 normal colon epithelium samples and 5 normal liver tissue samples hybridized on Human Sentrix-6 V2 (Illumina)

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Comparison of gene expression profiles between the CD110+ tumor initiating cells from primary colorectal tumors and their liver metastases.

Project description:We established an in vivo model of organ-specific colorectal cancer metastasis and demonstrated that the CD110+ tumor initiating cells contribute for colorectal liver metastasis. To gain a deeper understanding of its metastatic capacity, we performed a genome-wide transcriptome analysis on the CD110+ tumor cells derived from primary colon xenografts and their matched liver metastases. Results provide important information of the responses of the CD110+ cells during the process of liver colonization. Total RNA obtained from the CD110+ cells sorted from primary colorectal tumors (CRC102-PT and CRC108-PT) compared to those from the corresponding liver metastases (CRC102-LM and CRC108-LM).

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CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133- cells

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