Transcriptomics

Dataset Information

0

TXNRD1 drives innate immune response in senescent cells and promotes age-associated inflammation II


ABSTRACT: Sterile inflammation, also known as “inflammaging”, is a hallmark of tissue ageing. Cellular senescence contributes to tissue aging in part through secretion of proinflammatory factors known as senescence-associated secretory phenotype (SASP). Thioredoxin reductase 1 (TXNRD1) genetic variability is associated with aging and age-associated phenotypes such as late-life survival, activity of daily living, and physical performance at old age. TXNRD1’s role in regulating tissue ageing has been attributed to its enzymatic role in reducing reactive oxygen species. Here we show that TXNRD1 drives SASP and inflammaging through the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) innate immune response pathway independent of its enzymatic activity

ORGANISM(S): Mus musculus

PROVIDER: GSE204841 | GEO | 2023/05/25

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-05-25 | GSE202664 | GEO
2022-06-14 | MSV000089650 | MassIVE
2019-03-14 | GSE111841 | GEO
2009-06-24 | E-GEOD-16381 | biostudies-arrayexpress
2009-06-03 | GSE16381 | GEO
2024-03-15 | MSV000094326 | GNPS
2022-10-15 | PXD032757 | Pride
2024-01-24 | MTBLS1991 | MetaboLights
2024-11-01 | GSE247074 | GEO
2024-03-15 | MSV000094326 | MassIVE