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Ryk signaling in astrocytes modulates glial border formation and coordinates cellular interactions after spinal cord injury

ABSTRACT: After the data quality control, a total of 15,094 captured cells were subjected to clustering analysis by uniform manifold approximation and projection (UMAP) strategy. The results showed that there could be clustered into 20 distinct cell clusters. According to the highest differentially expressed genes (DEGs) and canonical markers used in prior studies, we annotated these 20 clusters as 10 major cell types with distinct expression profiles): astrocytes (ASC, containing 2 clusters: ASC_1 and ASC_2), microglia (MG, containing 2 clusters: MG_1 and MG_2), oligodendrocytes (containing 4 clusters), endothelial cells (containing 2 clusters), pericytes, fibroblasts, neuronal cells (NEU, containing 4 clusters: NEU_1 to NEU _4), ependymal cells(containing 4 clusters), blood cells and immune cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE205029 | GEO | 2024/11/30

REPOSITORIES: GEO

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