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Transcriptomic analysis of HIV-associated nephropathy (Tg26) mouse kidney [bulk RNA-seq]

ABSTRACT: We analyzed the transcriptomic profiles of Tg26 mouse kidney cortex by bulk mRNA-seq with or without treatment by PKR inhibitor (C16).

ORGANISM(S): Mus musculus

PROVIDER: GSE205058 | GEO | 2024/05/27

REPOSITORIES: GEO

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Transcriptomic analysis of HIV-associated nephropathy (Tg26) mouse kidney [single-nuclear RNA-seq]

Project description:We analyzed the transcriptomic profiles of Tg26 mouse kidney by single-nuclear RNA-seq with or without treatment by PKR inhibitor (C16).

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Transcriptomic analysis of HIV-associated nephropathy (Tg26) mouse kidney [bulk RNA-seq]

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Transcriptomic analysis of HIV-associated nephropathy (Tg26) mouse kidney

Project description:This SuperSeries is composed of the SubSeries listed below.

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Transcriptomic analysis of HIV-associated nephropathy (Tg26) mouse kidney [single-nuclear RNA-seq]

Project description:Transcriptomic analysis of HIV-associated nephropathy (Tg26) mouse kidney [single-nuclear RNA-seq]

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Transcriptomic data indicating differential expressed genes between HIV-1 Associated Nephropathy (HIVAN) mouse model (Tg26) and wildtype mice.

Project description:Tg26 mice are robust models of human immunodeficiency virus 1 associated nephropathy (HIVAN). These mice are useful for HIVAN pathology analysis, and recent studies suggest that the Tg26 mouse model is an excellent model of other chronic kidney diseases. We performed RNA seq analysis of differential gene expression in the kidneys of Tg26 mice. Kidneys were collected from Tg26 mice and wildtype (WT) littermates at 3 months of age. The raw data were analyzed for differential gene expression using a negative binomial generalized linear model in the DeSeq2 software package. We used P-Value ?0.05 and an absolute fold change of 1.5 to identify top 50 upregulated and top 50 downregulated differentially expressed genes between the WT and Tg26 mice. As expected inflammatory genes were among the top differentially regulated genes. Our data provides yet another level of information to help gain a more comprehensive understanding of disease progression and identify potential drug targets for HIVAN and chronic kidney diseases.

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Systems approach identifies HIPK2 as a critical regulator of kidney tubulointerstitial fibrosis

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