Direct reprogramming of adult adipose-derived regenerative cells toward cardiomyocytes using six transcriptional factors I
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ABSTRACT: It is widely accepted that adipose-derived regenerative cells (ADRCs) can differentiate into mesodermal lineage cells. However, reprogramming adult ADRCs into mature cardiomyocytes is challenging. We investigated the induction of myocardial differentiation in ADRCs via direct reprogramming using lentiviral gene transfer. We compared gene expression profiling from RNA sequencing of culture ADRCs and embryonic heart organ, and examined candidate transcriptional factors.
ORGANISM(S): Mus musculus
PROVIDER: GSE205165 | GEO | 2022/06/07
REPOSITORIES: GEO
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