Transcriptomics

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Gene expression profile of astrocytes derived from the cortex, hippocampus and hypothalamus of mice fed with standard chow (SC) or high-fat high-sugar (HFHS) diet


ABSTRACT: Astrocytes exhibit a high molecular diversity within the same, as well as across different brain regions. Moreover, astrocytes are characterized by a region-specific role in the regulation of neuronal circuitries, which might be affected by specific diseases. Regarding metabolic control, selective perturbations in astrocytes trigger multiple alterations in energy balance and glucose homeostasis. Using RNA sequencing, we showed that astrocytes have a distinct transcriptomic profile dependent on their anatomical location in the brain, which is affected by hypercaloric diet.

ORGANISM(S): Mus musculus

PROVIDER: GSE205313 | GEO | 2022/06/08

REPOSITORIES: GEO

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