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Genome-wide DNA methylation analysis of normal and adult primary refractory immune thrombocytopenia samples

ABSTRACT: Purpose:we'd like to provide the first DNA methylation profiling for ITP. Methods:Peripheral blood CD4+ T lymphocytes samples were collected from 4 primary refractory ITP cases and 4 age-matched healthy controls, and DNA methylome profiling was performed using Illumina Human Methylation850K. Results:The DNA methylome profiling identified a total of 260 differentially methylated CpG sites mapping to 72 hypermethylated and 64 hypomethylated genes. Conclusions:we performed genome-wide DNA methylation profiling of primary refractory ITP and healthy controls, and identified a set of differentially methylated genes and pathways.

ORGANISM(S): Homo sapiens

PROVIDER: GSE205495 | GEO | 2023/06/14

REPOSITORIES: GEO

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