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Regulation of DNA accessibility across the cell cycle by SWI/SNF complexes [ATAC-seq]

ABSTRACT: To identify dynamic changes in DNA accessibility with cell-cycle phase resolution following SWI/SNF inactivation, we compared the ATAC-seq signals in IMR32 cells treated with the small-molecule catalytic inhibitor of SWI/SNF BRM014 or DMSO, which were sorted by their cell cycle stage using a FUCCI live-cell fluorescent indicator. Analysis of these locations revealed that SWI/SNF-dependent sites are regulated in cyclic patterns throughout the cell cycle.

ORGANISM(S): Homo sapiens

PROVIDER: GSE205534 | GEO | 2023/10/24

REPOSITORIES: GEO

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