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Evaluating the presence of rare ERα-antagonism induced cells in WT tissues

ABSTRACT: To examine the effects of ERα antagonism (giredestrant) on Esr1-wildtype and Esr1-mutant mammary glands, animals were treated with hormone pellets (E2, P4), then dosed daily with vehicle (MCT) or giredestrant (30 mg/kg, p.o.) for four days. Following dosing, individual mammary epithelial cell populations were FACS-isolated and sequenced. Rare giredestrant-induced novel cells (at least 1000 cells per sample) were collected from WT tissues and compared to mutant-induced novel cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE205577 | GEO | 2024/10/31

REPOSITORIES: GEO

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