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RNA seq Analysis of Wild Type and CAMTA1 knockout SH-SY5Y cell line

ABSTRACT: We knocked out the CAMTA1 gene in SH-SY5Y cells and detected differences in RNA seq in wild-type and CAMTA1 KO cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE205687 | GEO | 2022/09/28

REPOSITORIES: GEO

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RNA seq Analysis of Wild Type and CAMTA1 knockout SH-SY5Y cell line

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Project description:The SH-SY5Y Human neuroblastoma cell line was subcloned from the SK-N-SH cell line, which has been isolated from a bone marrow biopsy of a 4 year-old female patient. To examine the overall distribution of gene expression under stress condition in human neuronal cells, we investigated changes in the transcriptome profiles in the SH-SY5Y cells exposed with sodium arsenite which causes oxidative stress. We detected changes in the expression levels for several genes including FOS and Jun, which are well-known stress-dependent upregulated genes.

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