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Gene expression of depletion of lncRNA Miat in mouse stem-like MB cells [miRNA-Seq]

ABSTRACT: To investigate the effect of gene alteration of Miat and Mtdh in mouse stem-like MB cells. by canonical oncogenic signaling to maintains the self-renewal capacity of a population of tumorigenic stem-like medulloblastoma cells that are resistant to cytotoxic therapy. by canonical oncogenic signaling to maintains the self-renewal capacity of a population of tumorigenic stem-like medulloblastoma cells that are resistant to cytotoxic therapy. Miat and Mtdh cooperate to promote medulloblastoma tumorigenesis and treatment resistance by regulating the biogenesis of a subset of microRNAs that target genes involved in these processes.

ORGANISM(S): Mus musculus

PROVIDER: GSE205694 | GEO | 2022/07/29

REPOSITORIES: GEO

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