Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23 [RNA-seq]

ABSTRACT: Genome-wide gene expression changes in response to mimicked hypoxia in undifferentiated MPC2 cells (mesenchymal stem cell-like) or 3-week osteogenic differentiated MPC2 cells (osteocyte-like)

ORGANISM(S): Mus musculus

PROVIDER: GSE205791 | GEO | 2023/01/24

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23 [ATAC-seq]

Project description:Genome-wide chromatin accessiblity changes in response to mimicked hypoxia in undifferentiated MPC2 cells (mesenchymal stem cell-like) or 3-week osteogenic differentiated MPC2 cells (osteocyte-like)

2023-01-24 | GSE205724 | GEO

Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-01-24 | GSE205792 | GEO

Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23

Project description:Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23

| PRJNA847602 | ENA

Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23 [ATAC-seq]

Project description:Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23 [ATAC-seq]

| PRJNA847246 | ENA

Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23 [RNA-seq]

Project description:Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23 [RNA-seq]

| PRJNA847597 | ENA

TF ChIP-seq from osteocyte (ENCSR300DWM)

Project description:CTCF ChIP-seq on osteocyte originated from osteocyte For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2021-05-23 | GSE175159 | GEO

Control ChIP-seq from osteocyte (ENCSR702WFF)

Project description:Control ChIP-seq on osteocyte originated from osteocyte For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2021-03-29 | GSE169778 | GEO

Osteoblast and Osteocyte Profiles at Different Cell-cummunication Status

Project description:Type of Experiment: 1) Profiles of Osteoblast vs. osteocyte in vitro; 2) Profiles of osteoblast low density vs. confluency in vitro; 3) Profiles of osteocyte with gap junction vs. without gap junction. Experimental factors: 1) 2T3 osteoblast cells at low density expressed extensive filopodia, reminiscent of early osteoblast precursors and similar to MLO-Y4 dendritic processes. 2) MLO-Y4 osteocytes at low vs. high density represent the genes that are changed in a highly connected network vs. low connected network. The number of hybridizations performed: Triplicate hybridizations for each status. Keywords = Osteoblast Keywords = Osteocyte

2010-06-09 | E-GEOD-2234 | biostudies-arrayexpress

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).

Project description:Cellular and physiological responses to changes in dioxygen levels in metazoans are mediated via the posttranslational oxidation of hypoxia-inducible transcription factor (HIF). Hydroxylation of conserved prolyl residues in the HIF-alpha subunit, catalyzed by HIF prolyl-hydroxylases (PHDs), signals for its proteasomal degradation. The requirement of the PHDs for dioxygen links changes in dioxygen levels with the transcriptional regulation of the gene array that enables the cellular response to chronic hypoxia; the PHDs thus act as an oxygen-sensing component of the HIF system, and their inhibition mimics the hypoxic response. We describe crystal structures of the catalytic domain of human PHD2, an important prolyl-4-hydroxylase in the human hypoxic response in normal cells, in complex with Fe(II) and an inhibitor to 1.7 A resolution. PHD2 crystallizes as a homotrimer and contains a double-stranded beta-helix core fold common to the Fe(II) and 2-oxoglutarate-dependant dioxygenase family, the residues of which are well conserved in the three human PHD enzymes (PHD 1-3). The structure provides insights into the hypoxic response, helps to rationalize a clinically observed mutation leading to familial erythrocytosis, and will aid in the design of PHD selective inhibitors for the treatment of anemia and ischemic disease.

| S-EPMC1502536 | biostudies-literature

Role of Piezo1-mediated mechanotransduction in osteocyte differentiation

Project description:Mechanical force is a fundamental regulator of bone development and homeostasis. Mechanosensitive osteocytes are the most abundant bone cells that form interconnected dendrites to respond to mechanical stimuli and interact with the bone-forming osteoblasts and the bone-remodeling osteoclasts. However, the molecular mechanisms underlying osteocyte maturation and dendrite formation remain unclear. By generating a Piezo1 "knock-out" osteocyte cell line, we identified a key role of Piezo1-mediated mechanotransduction in osteocyte differentiation. QRT-PCR analysis revealed delayed osteocyte differentiation in the Piezo1 KO cells relative to WT cells. By performing bulk RNA sequencing of WT and Piezo1 KO OCY454 cells at early (D1), intermediate (D14), and late (D28) stages of differentiation allowed for the identification of key signaling pathways in driving normal osteocyte dfiferentiation, as well as those regulated by Piezo1 mechanotransduction.

2024-09-20 | GSE277264 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data