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IL-13Ra1-mediated signaling regulates ABC expansion and lupus pathogenesis

ABSTRACT: ABCs are an emerging B cell subset that aberrantly expand in SLE. ABC generation and differentiation exhibit marked sexual dimorphism and TLR7 engagement is a key contributor to these sex differences. ABC generation is also controlled by IL-21 and its interplay with IFNg and IL-4. Here we investigated whether IL-13Ra1, an X-linked receptor that transmits IL-4/IL-13 signals, can regulate ABCs and lupus pathogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE206012 | GEO | 2022/06/16

REPOSITORIES: GEO

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